5 Also, some argue that the Wells rule is less safe in patients

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pandora bracelets For example, one study in primary care concluded that the combination of a low score on the Wells rule and a negative D dimer test result was unsafe https://www.jewellerydjflu.top, as it was associated with an unacceptably high proportion of missed cases.5 Also, some argue that the Wells rule is less safe in patients with an active malignancy6 7 or suspected recurrent deep vein thrombosis pandora rings,8 and in male patients,9 because in all these subgroups the actual prevalence of deep vein thrombosis is higher in the group suspected of having the condition. Therefore, although the Wells rule seems to be a valid tool in the clinical investigation of suspected deep vein thrombosis in unselected patients, its validity in various clinically important subgroups is unclear; most original diagnostic studies on deep vein thrombosis contained few patients in these important subgroups.To determine whether the Wells rule behaves differently in such subgroups we combined individual patient data from 13 diagnostic studies of patients with suspected deep vein thrombosis (n=10002).10 11 12 13 14 15 16 17 18 19 20 21 22 Such meta analyses of individual patient data (data of individual studies combined at patient level) provide a unique opportunity to perform robust subgroup analyses.MethodsStudy identificationBased on a previous meta analysis1 as well as contacts with experts in the specialty, we contacted all known principal investigators of published primary studies on the diagnosis of deep vein thrombosis that met the inclusion criteria. Apart from papers retrieved by our contacts with experts in the specialty, we found no additional papers pandora bracelets.

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